Abstract
Objective: The use of human induced pluripotent stem cells (hiPSCs) and recent advances in cell engineering have opened new prospects for cell-based regeneration therapy. However, there are concerns that must be addressed prior to their broad clinical applications such as treatment for Parkinson's disease, and a major concern is tumorigenicity. We here generated knock-in hiPSCs to analyze the feasibility of the herpes simplex virus thymidine kinase (HSV-TK) suicide gene system as a safeguard against tumorigenicity.
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