Abstract
Background Oral microbiota plays an important role in oral and systemic diseases, while few reports referred to obstructive sleep apnea syndrome (OSAS). Thus, this study aimed to explore the different salivary microbiome in patients with OSAS and controls. Materials and Methods Saliva was collected from 15 OSAS patients and nine healthy controls, and bacterial genomic DNA was extracted for 16S rRNA amplicon sequencing based on the Illumina platform. Results The alpha and beta diversities were not significantly different between patients with OSAS and controls. The main phyla in the two groups were Firmicutes, Actinobacteria, Bacteroidetes, Proteobacteria, and Fusobacteria, which accounted for 95% of the abundance. The main genera were Streptococcus, Rothia, Actinomyces, Prevotella, and Neisseria. Based on the genus and operational taxonomic units, Peptostreptococcus, Alloprevotella, and Granulicatella were enriched in controls, while only Scardovia species were significantly more abundant in patients with OSAS. Conclusions There was no significant difference in the relative abundance of bacteria between OSAS and controls. So, further studies will need to focus on the metagenome of bacteria in OSAS patients.
Highlights
Obstructive sleep apnea syndrome is a sleep-breath disorder caused by upper airway obstruction and characterized by recurrent hypoxemia and daytime sleepiness [1, 2]
Nine controls and 15 patients with severe obstructive sleep apnea syndrome (OSAS) patients were chosen for this study. ere were no significant differences in sex, age, and body mass index (BMI) between the two groups (Table 1). e apneahypopnea index (AHI) and oxygen desaturation index (ODI) indexes in OSAS patients were significantly higher than those in the controls
Because OSAS patients have apnea at night, which will lead to hypoxia, so the mean SaO2 and minimum SaO2 indexes were significantly lower in OSAS patients than those in the controls
Summary
Obstructive sleep apnea syndrome is a sleep-breath disorder caused by upper airway obstruction and characterized by recurrent hypoxemia and daytime sleepiness [1, 2]. It can occur at any age and lead to poor quality of life [3]. Intermittent hypoxia regulates hypoxia/reoxygenation cycles in the upper airway and gut, which increases the bacterial diversity in OSAS patients. E relative abundances of Streptococcus, Prevotella, and Veillonella were higher in the nasal fluid of severe OSAS patients than those in healthy subjects. Us, this study aimed to explore the different salivary microbiome in patients with OSAS and controls. Further studies will need to focus on the metagenome of bacteria in OSAS patients
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Schedule a callMore From: The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
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