Analysis of the risk factors related to prognosis of severe intra-abdominal infection in surgical intensive care unit

Abstract

To investigate the risk factors related to prognosis of patients with severe intra-abdominal infection (SIAI) in surgical intensive care unit (SICU). Clinical data of 69 patients with SIAI, who were hospitalized during January 2008 and April 2011 in SICU, were analyzed retrospectively. According to the outcome at discharge from SICU, 69 patients were divided into two groups: the survivors 42 cases; the deceased 27 cases. The potential risk factors of SIAI patients in SICU were analyzed by univariate analysis and logistic regression analysis. Univariate analysis showed that average acute physiology and chronic health evaluation II (APACHEII) scores (the survival group: 11.76 ± 3.48; the death group: 17.12 ± 4.50), inadequate treatment of intra-abdominal infection (3 survivors, 21 deceased), inadequate initial antibiotic treatment (3 survivors, 15 deceased) and septic shock (24 survivors, 27 deceased) were risk factors for mortality (all P < 0.01). Logistic regression analysis showed that average APACHEII scores over 15 [relative risk (RR): 6.846, P value: 0.044] and insufficient treatment of intra-abdominal infection (RR: 21.319, P value: 0.018) were the independent risk factors in SIAI patients in SICU. To decrease the mortality of SIAI patients in SICU, more attention should be paid to monitor APACHEII scores and to handle intra-abdominal infection adequately.