Analysis of the Results of Monitoring Arbovirus Infections in the Volgograd Region in 2019

A O Negodenko,V K Fomina,E V Molchanova,D N Luchinin,O A Pavlyukova,P Sh Konovalov,E A Skrynnikova,N V Boroday,D R Prilepskaya,I V Karunina

doi:10.31631/2073-3046-2021-20-1-51-59

Abstract

Relevance.Naturalandclimaticconditions,a variety of species composition of arthropods and vertebrates determine the possibility of circulation of arboviruses in the Volgograd region. The existence of natural foci of some arbovirus infections and the possibility of the formation of others suggests the need for annual monitoring of the causative agents of arbovirus diseases.Аim.EvaluationoftheresultsofmonitoringofarbovirusinfectionsintheVolgogradregionin2019.Materials and methods:806bloodserumsamplesfromdonors,44bloodserumsamplesfromfebrilesickpeople,300bloodserumsamplesfromhorsesand94poolsofblood-suckingmosquitoeswereexaminedbyimmunofernalanalysis.ResultofthestudyofserumsamplesfromdonorsintheVolgogradregion,in140(17.4%)of806werefoundtohaveantibodiestothepathogenofWestNilefever(in35(4.3%)– IgM, in 105 (13.0%) – IgG), in 7 (2.2%) of 319 – to the Crimean hemorrhagic fever virus (in 4 (1.3%) – IgM, in 3 (0.9%) –IgG), and in 7 (2.9%) of 240 – IgG to the viruses of the California serogroup. Specific antibodies against viruses of Sindbis, Batai and Uukuniemi in the samples was not detected. The largest number of positive samples with the presence of IgG and IgM to the West Nile virus was found among residents of Volgograd (61 out of 240, 25.4%) and Volzhsky (25 out of 100, 25, 0%). Among 44 blood serums of febrile patients, 1 sample (2.3%) was found to contain an antigen of the Sindbis virus, and 2 samples (4.5%) – antigens California serogroup viruses. Specific immunoglobulins against West Nile virus were detected in 84 (28%) of 300 blood serums of farm animals (horses). In the study of 94 samples of field material (blood-sucking mosquitoes), West Nile virus antigen was detected in 14 (14.9%), Sindbis virus – in one sample (1.0%), Batai virus – in four samples (4.2%). Conclusions:theobtainedresults,alongwiththecirculationofWestNilevirusandCrimeanhemorrhagicfevervirusvirusintheVolgogradregion,indicatethepresenceofSindbis,BataiandCaliforniaserogroupvirusesandnecessitatefurtherstudyoftheirroleintheinfectiouspathologyofthepopulation.

Highlights

For citation: Negodenko AO, Molchanova EV, Prilepskaya DR et al Analysis of the Results of Monitoring Arbovirus Infections in the Volgograd Region in 2019
Quantitative ratio of seropositive to WNV blood serum samples from donors of the Volgograd region depending on age Возраст доноров The age of the donor
Et al Second international diagnostic accuracy study for the serological detection of West Nile virus infection // PLOS Neglected Tropical Disease

Summary

Практические аспекты эпидемиологии и вакцинопрофилактики

В 140 пробах сывороток крови доноров (17,4%) из 806 были обнаружены антитела к возбудителю лихорадки Западного Нила (в 35 (4,3%) – IgM, в 105 (13,0%) – IgG), в 7 (2,2%) из 319 выявлены антитела к вирусу Крымской геморрагической лихорадки (в 4 (1,3%) – IgM, в 3 (0,9%) – IgG), в 7 (2,9%) из 240 – Ig G к вирусам Калифорнийской серогруппы. При изучении 44 сывороток крови лихорадящих больных в одной пробе (2,3%) были обнаружены иммуноглобулины класса M к вирусу Синдбис, в двух пробах (4,5%) – к вирусам Калифорнийской серогруппы. Результаты мониторинга свидетельствуют о продолжающейся активной циркуляции вирусов Западного Нила и Крымской геморрагической лихорадки на территории Волгоградской области, и, кроме того, обнаружение вирусов Синдбис, Батаи и Калифорнийской серогруппы обуславливает необходимость дальнейшего изучения вероятной роли последних в инфекционной патологии населения. Для цитирования: Негоденко А.О., Молчанова Е.В., Прилепская Д.Р.

Результаты и обсуждение Исследование сывороток крови

Нехаевский Nekhaevsky Даниловский Danilovsky Новоаннинский Novoanninsky

Новоаннинский Novoanninsky Урюпинский Uryupinsky

КСГ California

Findings

The number of positive samples