Analysis of the results of follow-up COVID-19 patients half a year after discharge in Chengdu

Abstract

Objective To summarize the follow-up results of COVID-19 patients half a year after discharge in Chengdu. Methods To collect the data of 48 COVID-19 patients who were cured and discharged from the hospital, we used SPSS 26.0 statistical software to analyze the results of laboratory examinations, cardiac color Doppler ultrasound, chest CT, and cardiac MRI half a year after discharge. Results Among the revisited patients, 4 cases (8.3%) were accompanied by dry cough, and 7 cases (14.6%) had decreased activity tolerance, the incidence of decreased activity tolerance in the severe group was higher than that in the non-severe group ( P 0.05). The positive rate of SARS-CoV-2 IgG was 68.8% (33/48), 3 patients had positive results of SARS-CoV-2 IgM, and all patients' SARS-CoV-2 nucleic acid were negative. 37.0% (17/46) of follow-up patients had heart valve regurgitation, 35.4% (17 /48) of follow-up patients had pulmonary ground-glass shadow lesions, and 10.4% (5 /48) had pulmonary interstitial grid shadow. The incidence of obvious ground-glass shadow lesions in lungs in the severe group was greater than that in the non-severe group ( P =0.001). Cardiac MRI results showed that 8 patients had myocardial edema, and 4 patients had myocardial microcirculation disorder. Conclusion Some COVID-19 patients have symptoms half a year after discharge, which are mainly manifested by dry cough and decreased activity tolerance. Infection with the SARS-CoV-2 may cause long-term myocardial damage to the patient. The liver function and T lymphocyte function have basically returned to normal half a year after discharge. Some patients have obvious ground-glass shadows in the lungs and lung function damage half a year after discharge. 摘要：目的 总结成都市新型冠状病毒肺炎(COVID-19)患者出院后半年的复诊结果。 方法 收集成都市48例复 诊的COVID-19患者资料 , 分为重症组和非重症组, 同时以医院45位健康医务人员为对照组, 使用SPSS 26.0统计学软 件整理分析复诊者出院后半年症状、实验室检査、心脏彩超、胸CT、心脏核磁共振结果, 以及复诊者CD4+T、CD8+T计数 与健康对照组的差异。 结果 复诊患者中伴干咳4例(8.3%), 活动耐量较患病前下降7例 (14.6%), 重症组活动耐量下 降的发生率髙于非重症组( P 0.05)。SARS-CoV-2 IgG的阳性率为68.8%, 例患者SARS-CoV-2 IgM阳性, 所有复诊患者咽拭子SARS-CoV-2核酸阴性； 37.0%复诊患者伴有心脏瓣膜反流;35.4%伴有肺部磨玻璃影病灶;10.4%伴有肺间质网格影。重症组肺部伴有明显磨 玻璃影病灶的发生率大于非重症组( P =0.001)。心脏核磁共振结果显示8例患者存在心肌水肿, 4例存在心肌微循环障 碍。 结论 部分COVID-19患者在出院后半年有症状, 主要表现为干咳及活动耐量较患病前下降, 感染新冠病毒可对 患者造成长时间的心肌损伤。出院后半年的肝功、T淋巴细胞功能已基本恢复正常。个别患者在出院后半年仍有明显 肺部磨玻璃影并伴有肺功能损伤。