Abstract
Background: The gastrointestinal system is innervated by the sympathetic and parasympathetic components of the autonomic nervous system (ANS). ANS mediate its effect by the release of acetylcholine, a neurotransmitter secreted by the parasympathetic nervous system. Its stimulation produces increase intestinal motility, sphincter muscle relaxation and stimulation of secretion. The actions of acetylcholine can be blocked by using a cholinergic receptor, antagonist such as atropine.Aims: This study is aimed at determining the effect of aqueous rhizome extract of Zingiber officinale on an isolated rat ileumResult: The aqueous extract of Zingiber officinale produced similar effect as atropine, as seen when varied increasing doses(1mg/ml, 2mg/ml, 4mg/ml) of the extract was administered. It produced significant inhibition (P< 0.05) at 1mg/ml (P< 0.01) at 2mg/ml (P< 0.001) and at 4mg/ml intestinal motility respectively , indicating anti diarrhoea effect.Keywords: Zingiber officinale, Acetylcholine, Atropine, Muscarinic receptor
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
