Abstract
Objective To explore the factors affecting coagulopathy after the procedure of transjugular intrahepatic portosystemic shunt (TIPS) for the treatment of portal hypertension. Methods The clinical data of 68 cases of patients with cirrhosis and portal hypertension were retrospectively studied and the relationship of the multivariate factors affecting coagulopathy was analyzed by multivariate logistic regression model. Results Thirty-one cases presented coagulopathy accounting for 45.6%. Single variate analysis showed that the sign of coagulopathy related to age, pervious episodes of bleeding, karnofsky performance status(KPS), Serum concentrations of prealbumin, distribution of the portal vein and portal vein flow volume before and after TIPS. Eventually the equations were calculated by forward selection of multivariate logistic regression model (x1,2, 3 represent pervious episodes of bleeding, prealbumin and portal vein flow volume after TIPS respectively). Conclusions The related factors of blood coagulation dysfunction after TIPS were preoperative serum concentrations of prealbumin, pervious episodes of bleeding and postoperative portal vein perfusion. Key words: Liver cirrhosis; Portasystemic shunt, transjugular intrahepatic; Coagulation dysfunction
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