Abstract
BackgroundGastric cancer is one of the most common cancers in the world and a major cause of cancer-related death. This study aims to determine whether genetic variations in MIR155HG could be associated with gastric cancer risk.Materials & methodsA total of 506 gastric cancer patients and 500 healthy controls were enrolled in this study. Genotypes were examined with the MassARRAY platform and data management and analysis were conducted with the Typer Software. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated with logistic regression adjusting for age and gender to evaluate the associations between SNPs with gastric cancer in genetic model analysis.ResultsThe “CC” genotype of rs4143370 decreased the risk of gastric cancer in genotype model (p = 0.020) and recessive model (p = 0.018). Inversely, the “CC” genotype of rs1893650 increased the risk of gastric cancer in genotype model (p = 0.023) and recessive model (p = 0.014). Stratified analysis showed that rs11911469 was associated with an increased risk of gastric cancer only among the male group in the dominant model (p = 0.039) and additive model (p = 0.030). The haplotype analysis showed a strong linkage disequilibrium among these six SNPs (rs4143370, rs77699734, rs11911469, rs1893650, rs34904192 and rs928883).ConclusionThis study confirmed the relationship between SNPs of MIR155HG and the gastric cancer risk among the Chinese Han population. Our data may provide a new perspective to understand the aetiology of gastric cancer.
Highlights
Gastric cancer is one of the most common cancers in the world and a major cause of cancer-related death
The basic information of selected Single nucleotide polymorphism (SNP) The basic information of the seven SNPs in MIR155HG shown in Table 2, including gene, chromosome, position, alleles, Minor allele frequency (MAF) in cases and controls and functional effects
The results showed that the SNPs of MIR155HG were involved in the regulation related to DNAase, mark the promoter histone, change motifs, GRASP QTL hits, enhance histones, and bind proteins, suggesting they might exert biology functions in these ways in gastric cancer
Summary
Gastric cancer is one of the most common cancers in the world and a major cause of cancer-related death. Gastric cancer was reported to be the third leading cause of cancer-related mortality [1]. The incidence of this cancer varies by region and ethnicity. Epidemiological studies have demonstrated that interaction of environmental factors and genetic factors has MicroRNAs (miRNAs) are a class of important noncoding RNAs that play a biological role by inhibiting the expression of their targets at the post-transcriptional level. MicroRNA-155 (miR-155) is a multifunctional miRNA that is involved in many disease processes including hematopoietic development [7, 8], Zou et al BMC Gastroenterology (2020) 20:17 inflammatory responses [9, 10], autoimmune [11], and tumorigenesis [12, 13]. MiR155 is a transcription product of its host gene (MIR155HG), and its expression may be affected by genetic variations of the MIR155HG gene
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