Analysis of the relationship between MCI and metabolic syndrome‐related factors in community residents over 50 years old

Abstract

AbstractBackgroundCurrent studies had shown that cognitive impairment related to metabolic syndrome, but the relationship between the two has not determined absolutely. Mild Cognitive impairment (MCI) has a high incidence in cognitive impairment and is the early stage of dementia. The analysis of the correlation between MCI and metabolic syndrome related factors can help prevent and cure mild cognitive impairment in the early stag, and reduce the occurrence of dementia and reduce the social burden.MethodWe enrolled 235 cases in community over the age of 50 years. We used the Montreal Cognitive Assessment (MoCA) to assess cognitive function, screening the patients with mild cognitive impairment, and Analyzed the cognitive function and factors associated with metabolic syndrome, such as creatinine (CREA), urea(UA), blood glucose (GLU), low density lipoprotein cholesterol (LDL), very low density lipoprotein cholesterol (VLDL), body mass index (BMI), waist hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure(DBP).ResultThe prevalence of mild cognitive impairment was about 79.2%)n=187( among community residents over 50 years old. Comparing to normal cognitive function group and mild cognitive impairment group, the blood glucose and systolic blood pressure showed significant differences( (P<0.05)),and no significant differences in CREA,UA,LDL,VLDL,BMI,WHR,DBP. Compared to normal blood glucose group, the score of executive, calculation and naming in high blood glucose were decreased, and the differences were significant (P<0.05). Compared to normal systolic blood pressure group, the Score of letter fluency in high systolic blood pressure was decreased, and the differences was significant (P<0.05).ConclusionThe incidence of MCI in community residents over the age of 50 was high, which was closed related to blood glucose and systolic blood pressure. High blood glucose can reduce the patient’s ability of executive, calculation and language, and high systolic blood pressure can reduce letter fluency. Control the metabolic syndrome related factors, can reduce the incidence of mild cognitive impairment, benefit to the life quality of community residents.