Analysis of the relationship between concentration of arterial blood lactic acid and prognosis of patients with septic shock

Abstract

Objective To study the relationship between concentration of arterial blood lactic acid （ BLA）and prognosis of patients with septic shock in respiratory intensive care unit（ RICU）. Methods From January 2012 to June 2012,49 patients with septic shock were divided into survival group and death group according to the prognosis. The levels of arterial BLA and results of blood gas analysis were compared between the two groups. Results The levels of arterial BLA in the two groups after being admitted into RICU were significantly higher than the normal range and gradually decreased with continuation of treatment. The levels of arterial BLA in patients of survival group at 0,6,24 and 48 h after being admitted into RICU were distinctly lower than those in death group. The 6 h lactate clearance of patients in survival group was remarkably higher than that in death group. Conclusions The septic shock patients with higher arterial blood lactic acid often has poor prognosis,and the prognosis of patients with low lactate clearance at 6 h after being admitted into ICU is relatively worse. Key words: Septic shock; Blood lactic acid; Lactate clearance; Prognosis