Abstract

Haplogroup R1b-M269 comprises most Western European Y chromosomes; of its main branches, R1b-DF27 is by far the least known, and it appears to be highly prevalent only in Iberia. We have genotyped 1072 R1b-DF27 chromosomes for six additional SNPs and 17 Y-STRs in population samples from Spain, Portugal and France in order to further characterize this lineage and, in particular, to ascertain the time and place where it originated, as well as its subsequent dynamics. We found that R1b-DF27 is present in frequencies ~40% in Iberian populations and up to 70% in Basques, but it drops quickly to 6–20% in France. Overall, the age of R1b-DF27 is estimated at ~4,200 years ago, at the transition between the Neolithic and the Bronze Age, when the Y chromosome landscape of W Europe was thoroughly remodeled. In spite of its high frequency in Basques, Y-STR internal diversity of R1b-DF27 is lower there, and results in more recent age estimates; NE Iberia is the most likely place of origin of DF27. Subhaplogroup frequencies within R1b-DF27 are geographically structured, and show domains that are reminiscent of the pre-Roman Celtic/Iberian division, or of the medieval Christian kingdoms.

Highlights

  • Haplogroup R1b-M269 comprises most Western European Y chromosomes; of its main branches, R1b-DF27 is by far the least known, and it appears to be highly prevalent only in Iberia

  • DF27 was first discovered by citizen scientists[14] and, among the burgeoning amateur genetic genealogy it is known to be frequent in Iberian populations and their overseas offshoots, few academic publications have been devoted to it

  • Most (50–100%, with a proportion that dropped from East to West) DF27 Y chromosomes were derived for Z195; the highest frequencies of Z195 (0.29–0.41) were reached both in the Basque Country and in E Iberia (Catalonia, Valencia), and it becomes as rare in Portugal as it is in France

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Summary

Introduction

Haplogroup R1b-M269 comprises most Western European Y chromosomes; of its main branches, R1b-DF27 is by far the least known, and it appears to be highly prevalent only in Iberia. Subhaplogroup frequencies within R1b-DF27 are geographically structured, and show domains that are reminiscent of the pre-Roman Celtic/Iberian division, or of the medieval Christian kingdoms It contains ~1% of the genome length in a human male cell, the lack of recombination along most of the Y chromosome makes constructing phylogenies for genetic variation relatively easy. DF27 was first discovered by citizen scientists[14] and, among the burgeoning amateur genetic genealogy it is known to be frequent in Iberian populations and their overseas offshoots, few academic publications have been devoted to it It was found in the 1000 Genome Project populations at a frequency of 49% in Iberians, 6% in Tuscans, 7% in British, and it was absent elsewhere except for admixed populations in the Americas: Colombia (40%), Puerto Rico (36%), Mexico (10%), Perú (8%), African-Americans (4%) and Afro-Caribbeans (2%)[14, 15]. R1b-S116 (x L21, U152) was found at frequencies 0–10% in Germany3, 18, 7% in the Netherlands3, 8–12% in Flanders19, 6–12% in Switzerland[3], and 1–12% in Italy[3, 20]

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