Analysis of the prevalence and severity of clinical manifestations of papillomavirus infection in HIV-infected women of childbearing age

Abstract

Objective: to determine the prevalence and severity of clinical and cytological manifestations of papillomavirus infection in HIV-infected women of childbearing age in relation to immunological and virological parameters.Materials and methods. Statistical data were obtained through direct randomised inclusion of 182 HIV-infected women of fertile age who were being followed up at the AIDS Centre during their initial gynaecological examinations. Statistical processing of the findings was carried out using IBM SPSS Statistics software.Results and discussion. The results of the study showed a high detection rate of chronic papillomavirus infection of high carcinogenic risk (HPV HRS) among HIV-infected women, which is a prognostically unfavorable factor for the development of pathological changes in the cervix and was confirmed in a study by extended colposcopy. It was found that the concentration of HPV VKR increases against the background of a decrease in the immune status, and there is an indirect relationship between the level of HIV viral load and the concentration of HPV VKR.Conclusion. The feasibility of HPV vaccination among HIV-infected girls and women aged 9–45 has been demonstrated.