Abstract

Overactive bladder (OAB) is a prevalent condition characterized by lower urinary tract symptoms (LUTS). Age, education, income, marital status, sleep, and emotional problems have been associated with OAB; however, conflicting results exist. The present study was conducted to estimate the prevalence of OAB and comprehensively analyze its associated factors in a large cross-sectional, population-based study. The data of 94,554 participants aged 19–107 were analyzed from the Korean Community Health Survey (KCHS) of 2012. Data on marital status, physical activity, education level, occupation, body mass index (BMI), income level, sleep time, and stress level were retrieved for all enrolled participants. The overactive bladder symptom score (OABSS) was used to evaluate the presence and degree of OAB. Simple and multiple logistic regression analyses with complex sampling were used for the associations between various factors and the presence of OAB. Overall, OAB was present in approximately 2.9% of the participants. The prevalence of OAB increased with age and steeply increased after 60 years of age (adjusted odds ratio [AOR] for each 10 years = 1.70, 95% confidence interval [CI] = 1.61–1.80, P<0.001). The prevalence of OAB was lower in married than unmarried subjects (AOR = 0.59, 95% CI = 0.48–0.72, P<0.001). The prevalence of OAB was significantly different according to occupation Compared to manager, expert, specialist, clerk group, the prevalence of OAB was highest in unemployed group (AOR = 1.90, 95% CI = 1.55–2.32, P < 0.001). Being underweight was correlated with OAB (AOR = 1.29, 95% CI = 1.08–1.55, P = 0.018). Inadequate sleep showed a significant association with OAB (AOR = 1.13, 95% CI = 1.02–1.25 for ≤6 hours of sleep time and AOR = 1.53, 95% CI = 1.27–1.86 for ≥9 hours of sleep, P<0.001). Stress level showed a dose-dependent positive association with OAB [AOR (95% CI) = 3.91 (3.13–4.89) > 2.16 (1.88–2.48) > 1.39 (1.23–1.57) for severe stress > moderate stress > some stress, respectively, P<0.001]. A medical history of diabetes mellitus, hyperlipidemia, and/or cerebral stroke was significantly related to OAB. Approximately 2.9% of adult Korean men experienced OAB based on the OABSS. Unmarried status; occupation; being underweight; inadequate sleep; stress; and medical history of diabetes mellitus, hyperlipidemia, or cerebral stroke were significantly correlated with OAB.

Highlights

  • Overactive bladder (OAB) is characterized by lower urinary tract symptoms (LUTS), including urgency and frequency of urination, associated with storage problems and nocturia [1]

  • As the prevalence of OAB increased with age, the mean age of OAB (58.6 years of age, 95% confidence interval (CI) = 57.8–59.4) was higher than the normal control group (44.2 years of age, 95% CI = 44.1– 44.3) (P

  • The percentage of married subjects who experienced OAB was 3.4%, which was significantly more than the 1.5% of unmarried subjects who experienced OAB (P

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Summary

Introduction

Overactive bladder (OAB) is characterized by lower urinary tract symptoms (LUTS), including urgency and frequency of urination, associated with storage problems and nocturia [1]. OAB has received much attention because of its high prevalence and various impacts on life. Depending on the study population and investigation methods, the prevalence of OAB was estimated to be as low as 6.0% in the adult population in China and as high as 45.9% in the African-American population [5, 6]. OAB is known to be detrimental to the overall quality of life because of its impact on physical, emotional, and social aspects [3, 7, 8]. OAB is related to the various psychological problems of sleep disturbance, low self-esteem, depression, and anxiety as well as urinary complaints and subsequent diminished sexual activity [9]. Unemployment was approximately 1.5 times higher in men with OAB than in normal controls [12]. OAB is associated with a large economic burden [3, 7, 8]

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