Analysis of the preferences for splice codes across tissues.

Tao Huang,Yu-Dong Cai,Meng Wang

doi:10.1007/s13238-015-0226-5

Abstract

Analysis of the preferences for splice codes across tissues.

Highlights

Alternative splicing (AS) is a post-transcriptional process that can add complexity to proteome greatly by producing multiple different mature transcripts from the same pre-RNA (Black, 2003)
Some of the features we identified were supported by existing reports, while others provided guidelines for further experimental studies
Note that several splicing elements, such as the 5′ splice site, 3′ splice site, branch site and polypyrimidine tract, are needed in almost all kinds of splicing processes (Black, 2003), it is expected that there must be other motifs contribute to tissue-specific manner, and the preference of some motifs should be different in different tissues

Summary

Analysis of the preferences for splice codes across tissues

Dear Editor, Alternative splicing (AS) is a post-transcriptional process that can add complexity to proteome greatly by producing multiple different mature transcripts from the same pre-RNA (Black, 2003). Several small nuclear RNAs and more than 100 proteins are incorporated, forming many associated complexes (snRNPs), the combination of which is called “spliceosome” (Matlin et al, 2005) These snRNPs can recognize and bind with these sites, further mediate the removal of introns and the joint of exons. In addition to these sites, plenty of other cis-acting elements or motifs have been identified to be associated with the splicing activity of genes. These elements or motifs, or splicing regulation elements (SREs), include well documented or predicted exon splicing enhancers and silencers (ESEs and ESSs), and intron splicing enhancers and silencers (ISEs and ISSs). The preference of the key features may illustrate the splicing difference between tissues

Number of features

Feature occurrence

Findings

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