Abstract
The rheological properties of the new excipients A-, Di- and Tri-tab® were in general better than those of Emcompress®, whereas a mixture of Emcompress® with magnesium stearate exhibited the best flow characteristics and the lowest coefficient of tablet weight variation. Granulometry of the xcipients demonstrates that Tri-tab® has a maximum mean diameter and a wide particle size distribution, while Emcompress® has a particle size distribution similar to that of Di-tab®. Different compression properties, namely, net work, compactibility, plasticity and ejection work were evaluated after adding a hydrophobic lubricant to the wall of the die. The compressional properties demonstrated the values of the friction parameters to be insufficient in the cae of Di- and Tri-tab® powders, therfore, lubrication would be a major factor in tableting with these excipients for direct compression. Absolutely different compressional behavior of Di-tabl was observed. Moreover, the parameters obtained from the Heckel in die tablet method were calculated in order to establish the comparative consolidation mechanisms in the excipients under study. Emcompress® showed a lower extent of brittle fracture and greater plasticity than the other calcium phosphate-based excipients.
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