Abstract

Objective To analyze the performance of contrast-enhanced ultrasound (CEUS) in the evaluation of response to neoadjuvant chemotherapy (NAC) for breast cancer in different periods. Methods A prospective study consisting of 46 patients with invasive ductal carcinoma who received NAC and surgery subsequently was conducted. One patient underwent CEUS before NAC, after the second cycle of NAC and before surgery. CEUS outcomes were compared with histopathologic response by Kappa test using the Miller-Payne Grading (MPG) system. The changes of CEUS quantitative parameters in different periods of NAC were compared. Results 31 patients showed a good response by histopathology while 29 patients by CEUS, which showed good consistence. Kappa value was 0.713. The peak intensity (PI) of the lesions decreased significantly after the second cycle of NAC compared with that before NAC (P<0.05) . The peak intensity (PI) , wash-in slope (WIS) , and area under curve (AUC) of the lesions decreased significantly before surgery compared with those before NAC (P<0.05) . Conclusion CEUS shows good consistence with histopathologic outcomes. The peak intensity (PI) is a sensitive indicator of early changes after NAC. Key words: Contrast-enhanced ultrasound; Breast cancer; Neoadjuvant chemotherapy; Response evaluation; Ultrasonography

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.