Abstract
The object of this study was to determine the role of oxidative stress in development of learning and memory impairment observed in the senescence-accelerated prone mouse (SAMP8). We measured the lipid hydroperoxide levels in the brain and peripheral organs of SAMP8 at 3, 6, 9 months of age by HPLC, and compared the results with those of age-matched SAMR1 (control mouse). Although lipid hydroperoxide levels in the brain did not show an age-dependent change within either SAMP8 or SAMR1, the levels were significantly higher for SAMP8 than SAMR1 at each age examined. In contrast to the brain results, lipid hydroperoxide levels in the peripheral organs increased with aging in both substrains, and were higher in SAMP8 than SAMR1 at 3 and 6 months of age. The increase in lipid hydroperoxide levels observed in the brain of SAMP8 may be related to the development of senescence-related cognitive impairments in that substrain. In addition, analyses of lipid components in the brain and liver showed that phospholipids comprised more than 50% of the total lipid content in brain and liver of both substrains. However, the phospholipid hydroperoxide levels were almost negligible in the brain and liver of both substrains.
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