Abstract
Analysis of the Oxidative Stress Parameters in Testicular, Hepatic and Renal Tissues Homogenates of Albino Rats after Administration of Imatinib at Peripuberty
Highlights
Targeted small molecule drugs have revolutionized treatment of chronic myelogenous leukemia (CML) over the last two decades
This study revealed a decrease in value of GSH in the testicular and hepatic tissues of the treated rats, the concentrations of this antioxidant in renal tissue were higher than that of control ones Fig. (1)
Imatinib induced an elevation of MDA productions in both testicular and hepatic tissues when compared to the control group Fig. (2)
Summary
Targeted small molecule drugs have revolutionized treatment of chronic myelogenous leukemia (CML) over the last two decades. Methods: This work included 40- 45 days aged rats (at peripuberty) (n=8) which administered a single daily dose of 200mg/kg of imatinib mesylate for 30 days (100mg capsule, Glivec®, STI 571; Novartis) bought from Ibn-Sena Teaching Hospital, Mosul, Northern Iraq, or bought from some private pharmacies and were dissolved in distilled water (D.W) and given orally by gavage with 24 gage needle. Another group of 8 rats were administered with D.W represents an age matched control. Conclusion: Imatinib induced a decrease in the level of GSH and increased in level of MDA in testicular, hepatic homogenates indicating its oxidative effect
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