Abstract
Mutations in the tumor suppressor genes BRCA1 and BRCA2 predispose women to cancer and are associated with diminished ovarian reserve through a known impairment in DNA repair function. The PI3K/AKT/mTOR pathway regulates primordial follicle activation, and its dysregulation is implicated in human cancers including BRCA-related ovarian cancers. We sought to investigate whether mTOR activity is upregulated in follicles of women with BRCA mutations, suggesting a potential factor contributing to diminished ovarian reserve.
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