Abstract
Background: Hepatocarcinogenesis is a multistep process entailing the transitions from normal liver_ chronic hepatitis and cirrhotic nodules (CH/CNs) _ dysplastic nodules (DNs) _hepatocellular carcinomas (HCCs). We hypothesized that hepatocarcinogeneis on top of chronic hepatitis C (CH-C) is associated with alterations in the mononuclear inflammatory cell infiltrate (MICs) in response to altered antigenicity of the damaged hepatocytes. Materials and methods: A total of 19 hepatic resection specimens entailing the entire continuum of the lesional steps of the hepatocarcinogenesis (on top of CH-C) were evaluated for MICs using immunohistological methods and mouse monoclonal antibodies (CD3, CD20, CD68 and T-cell intracellular associated antigen, TIA-1). Results: HCCs were: 1) overrepresented in elderly males (56.1 ± 2.0 years, with male to female ratio of 1.8:1), and 2) more common in the right than in left lobe (1.1:1).The transitions from normal liver to the subsequent lesional steps (CH-C/CNs, DNs and HCCs) was associated with statistically significantly (p
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