Analysis of the mechanism of right cerebellum in language using resting state functional magnetic resonance imaging

Abstract

Objective To elucidate the generation mechanism of cerebellum in language by resting state functional magnetic resonance imaging (fMRI).Methods Siemens verio 3.0T MR Scanner was used to obtain all of the subjects of fMRI data.The fMRI data were processed with the software of Data Processing Assistant for Resting-State fMRI Analysis Toolkit.Firstly,12 patients with poststroke aphasia and 20 normal controls were analyzed by amplitude of low frequency fluctuation (ALFF) and performed with two sample t-test by REST software; Secondly,decreased ALFF of certain brain regions of the cerebellum were selected as the regions of seed point and ROI,and then calculated the single sample t-test in normal controls to obtain function connectivity map.Results As compared with those in normal subjects,the regions showing decreased ALFF in aphasia patients were distributed in left middle temporal gyrus,left medial prefrontal gyrus,fight cerebellum.Positive functional connectivity with certain brain regions of the cerebellum ROI was seen in cerebellum tonsil,left middle temporal gyrus,left medial superior frontal gyrus and supplementary motor area.Conclusion Right cerebellum itself and through its impact on the presence of functional connections and structural connections of the brains participate in language production. Key words: Cerebellum; Aphasia; Magnetic resonance imaging