Analysis of the Lung Donors in the Chinese Mainland

Abstract

Background The report of Chinese lung donor in the new era (Criminals’ organ donations after their death has been forbidden officially since January 1, 2015). This a study to summarize the assessment, maintenance and procurement of donors’ lungs in 2017. Methods: From February 27, 2017 to December 4, 2017, a total of 107 donors were evaluated by the lung transplantation center of China-Japan Friendship Hospital. They were allocated to our hospital by the National Network for Organ Sharing. According to the geographic regional principle, the percentage of donors from Beijing, Tianjin relatively high. This paper intends to report the present situation of lung donation in China by analyzing various factors, including donors’ region, gender, ages, smoking history, reasons of brain death, ventilation time, pulmonary infection level, liquid management strategy, the ratio of final procurement, the reasons of abandonment, then a cross-sectional study was carried out by statistical analysis. Results: The data were analyzed by using SPSS 19.0 of the 107 donors, 92 were men, accounting for 85.98%, and 15 were women, 14.02%. The distribution of donor region is crossing the whole country. Beijing has the most donations and Tianjin is the second, the details are as follows: Beijing (70 cases, 65.42%), Tianjin (13 cases, 12.15%), Shandong province (7 cases, 6.54%), Guangdong province (6 cases, 5.61%), Zhejiang province (2 cases,1.87%). As for the blood type, type A Rh (+) is 20.56%, type B Rh (+) is 35.51%, type O Rh (+) 37.38%, type AB Rh (+) 6.54%. Ages range from 14 to 66 years old; the mean age is (35.97 ± 11.413) years old. Among them, age 40-49 is the most distribution (38 cases, 35.51%). The ventilation time is (7.64 ± 18.36) days. The group of age 20-29 have the longest ventilation time (16.59 ± 40.76) days. Brain vessel hemorrhage is the most important cause of brain death, accounting for 57.01%(61 cases, followed by brain injury (32 cases, 29.90%), cerebral infarction (5 cases, 4.67%), brain tumor (4 cases, 3.74%). Of the 107 donors, 76 were eventually procured. The proportion of organ procurement is 71.03%. The main causes of abandonment are lung infection (58.06%) and pulmonary edema (32.26%), or both (9.68%). The smoking rate of all donors is 28.97%, the smoking rate of the abandoned donors is 32.25%. The smoking index was not significantly related with P/F (R=0.31, p>0.05). Positive balance intravenous liquid group and the negative balance group have not statistically significant difference. Independent sample t test (F=0.054, P=0.270). Conclusion Our lung transplantation center is on the right track in the Chinese New Era and can be introduced to the international associations. Maintenance of donor’s lung strategy in ICU needs to be strengthened to improve the percentage of lung procurement.