Abstract
Background: The International Study Group of Liver Surgery (ISGLS) established the first internationally standardized definitions and grading for posthepatectomy hemorrhage (PHH), posthepatic liver failure (PHLF) and bile leakage. We aimed to evaluate and validate these new definitions in a center. Methods: 415 patients underwent hepatic surgery between 2004 and 2014. Uni- and multivariate analyses were made for correlations of PHH, PHLF and bile leakage with perioperative parameters and mortality. Results: 25 (6.1%) patients developed a PHH Grade A, 3 (0.7%) patients a PHH Grade B and one (0.2%) patient a PHH Grade C. 23 (5.5%) patients had a PHLF Grade A, 24 (5.8%) patients a PHLF Grade B and 7 patients (1.6%) a PHLF Grade C. Bile leakage Grade A occurred in 10 (2.4%) patients, bile leakage Grade B occurred in 24 (5.8%) patients, and bile leakage Grade C occurred in 7 (1.6%) patients. Mortality was significantly increased in patients with PPH Grades B and C and in patients with PHLF Grades A, B, and C. Three (42.9%) patients with bile leakage Grade C died. Conclusion: Our data indicate that the new definitions correlate well with mortality and duration of hospital stay.
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