Abstract
Recently, the interaction between graphene and biological membranes has been under intensive research because graphene and its related materials exhibit distinctive characteristics. For example, water-soluble graphene oxide (GO) is expected to be used as a carrier of drug delivery systems (DDS), but it is also known to have cytotoxicity. Thus, it is important to understand the interaction between lipid bilayers and graphene/GO in order to design molecular systems. Furthermore, these interactions have been studied mostly using small lipid vesicles (< 1 μm), although the size of biological cells is much greater. In this study, we studied the interaction between GO and cell-sized giant unilamellar vesicles (GUVs). We especially examined the effect of the lipid compositions, including neutral, negatively charged, and pyrene-grafted lipids. Pyrene is known to adhere to graphene with the non-covalent π-π stacking interaction. Microscope observations and flow cytometry measurement revealed that GUVs composed of lipids which have attractive interaction with GO rupture at a high probability.
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