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Abstract
The accelerating effect of whole human red blood cells (RBC) on the thrombin time of plasma (deprothrombinized, platelet-deprived) is manifested regardless of the presence or absence of calcium ions or of preincubation of the RBC with plasma and it is not accompanied by a fall of the free heparin level in the plasma. Acceleration of the transformation of the plasma fibrinogen into fibrin under the influence of whole RBC is unconnected with inhibition of endogenous heparin but reflects the fibrinoplastic effect of the cell. The experimental results do not support the view expressed in the literature that whole erythrocytes have a regulating effect on the blood level of endogenous heparin.
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