Abstract
In this article data on the analysis of the effect of transgenic Kalanchoe pinnate extract with cecropin P1 on the state of uninfected wounds in rats are presented. The study used Wistar rats weighing 220 ± 20 g. A wound of 20 × 20 mm was modeled under anesthesia in sterile conditions. The wound was treated during 14 days with the 3% hydrogen peroxide solution in all experimental groups. Additional treatment with the 10% cefazolin solution was used in group No. 2; with Kalanchoe juice it was used in group No. 3, and with transgenic Kalanchoe extract cecropin P1 it was used in group No. 4. The effectiveness of the treatment of the wound process was evaluated by the external state of the wound and planimetry indicators. It was found that all analyzed parameters of the experimental groups were better than in the control group of animals. However, the effect was most pronounced in the group treated by transgenic Kalanchoe extract with cecropin P1, The results of the study allow us to recommend further preclinical study of the substance for the possible treatment of trophic ulcers in patients with diabetes mellitus.
Highlights
Genetic engineering methods help to synthesize proteins in the cells of various organisms that can be used for therapeutic purposes
Transgenic plants can be promising objects for the synthesis of recombinant proteins, as well as safe and rather cheap compared to producers of recombinant proteins obtained by the traditional method
Purpose of the Study The purpose of the study was to analyze the effect of transgenic Kalanchoe extract with cecropin P1 on the state of an uninfected wound in rats
Summary
Genetic engineering methods help to synthesize proteins in the cells of various organisms that can be used for therapeutic purposes. In this regard, transgenic plants can be promising objects for the synthesis of recombinant proteins, as well as safe and rather cheap compared to producers of recombinant proteins obtained by the traditional method. As for the production of transgenic plants, Kalanchoe antimicrobial peptides, there are isolated publications on the transformation of some of these plant species. Effective methods for transforming Kalanchoe are not developed for all species. Transgenic Kalanchoe plants of the species Kalanchöe daigremontiana, K. laciniata, and K. blossfeldiana have been obtained [1,2,3]. The Kalanchoe species K. pinnata (Kalanchoe pinnate) is considered the most valuable for pharmacology
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