Analysis of the influence of inner morphology on blood flow in 3D-printed bone scaffolds

Abstract

In recent years, 3D printed scaffolds have been proposed as promising alternative to the conventional cell culture techniques. Scaffolds, indeed, allow the development of a higher number of cellular connections along the three dimensions favoring the cell regeneration, which make them particularly suitable in case of implants for deteriorate bones in old age patients. Besides the characteristics of biocompatibility and biodegradability fundamental for the integration of the scaffolds with the human body, the inner morphology, the permeability as well as the porosity are parameters of paramount relevance in the design of 3D-printed scaffolds influencing the flow of the blood through the cells and, thus, their metabolic functions. In the present work the influence of the internal geometry of 3D-printed scaffolds on the blood flow was investigated. Five cylindrical scaffolds having different internal geometry and different porosity were fabricated using parametric design technique. Numerical analysis of the blood flow within the designed structures was conducted by using CFD tool.