Analysis of the incidence and relevant factors of retinopathy of prematurity among 109 pairs of twin premature infants

Abstract

Objective To explore the incidence and related factors of retinopathy of prematurity (ROP) in twins. Methods The incidence and related factors of 109 pairs of twin premature infants were analyzed retrospectively in 218 cases of premature retinopathy screening in the Maternal and Child Health Hospital of Jiaxing during January 2012 to February 2014 Sex, birth weight, nasal oxygen breath, continuous positive airway pressure (CPAP), mechanical ventilation, blood transfusion, and others concominant disease such as asphyxia, sepsis, respiratory distress, congenital heart disease, and hypoglycemia were recorded. Two-sample t test and Logistic regression analysis were used to investigate the risk factors of ROP. Results The incidence of ROP in twin premature infants was 10.56%. There was no significant difference (P>0.05) of the incidence of ROP between lighter and heavier groups. When compared ROP group to normal fundus of premature babies in gestational age, birth weight, and Apgar score, postnatal pulmonary surfactant application, nasal oxygen breath, CPAP, mechanical ventilation, blood transfusion, anemia, asphyxia, respiratory distress, hypoalbuminemia, septicemia hypoglycemia, pulmonary hyaline membrane disease, congenital heart defects, there were statistical differences (P<0.05). Logistic regression analysis indicated that low gestational age, asphyxia, septicemia and hypoglycaemia were the possible risk factors of ROP. Conclusions The weight of twin premature infants is not a major risk factor for ROP. Gestational age, asphyxia, septicemia, and hypoglycaemia are the most important risk factors in the development of ROP. Key words: Twins; Retinopathy of prematurity; Incidence