Analysis of the impact of comorbidities in the mortality of patients that were hospitalized with Covid-19

Abstract

Introduction: SARS-CoV-2 has resulted in a pandemic since March 2020. The knowledge of the impact of risk factors is fundamental for its adequate treatment. This study aims to analyze the impact of comorbidities and transplant of solid organs and tissues in patients who were hospitalized because of Covid-19. Methods: There were collected data from 457 patients that had been diagnosed with Covid-19 who were hospitalized in a ward or in an intensive care unit (ICU) at a university hospital. All the patients were sorted for history of transplant of solid organs and tissues. The laboratory results of admission, place of hospitalization and outcome were compared among the group of transplanted and non-transplanted patients. Results: In total, there were collected 457 patient’s data that had been diagnosed with Covid-19. The lethality in our service was 17,94%. The mortality of patients hospitalized in ICUs was 57,14%. The patients that presented hypertension (48,36%) showed a mortality level of 23,53% versus 12,71% who did not. Differently from the previous comorbidity, DM-2 showed no statistical significance. Transplanted patients had 2,13 more chances of being hospitalized in the ICU than in the ward. Also, transplanted patients had 2,21 more chances of death. The mortality in kidney transplant patients was 35.29%, liver transplant was 23.08% and allogenic bone marrow transplant 33.33%. Conclusion: In our sample of patients that had been hospitalized with COVID-19, the prior diagnosis of hypertension and transplant showed higher levels of mortality, mainly kidney transplantated patients (35.29%).