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Abstract
Analysis of the GJB2 Gene and its Mutated Protein in Non-Syndromic Hearing Loss Patients of Gilgit-Baltistan
Highlights
The current study aimed at genetic analysis of by Cirrhinus mrigala using mitochondrial DNA marker cytochrome oxidase I (COI)
A partial sequence of COI gene was used and a consensus sequence of 649 bp was applied for further data analysis
A low level of genetic divergence was found among the samples of C. mrigala captured from four different sites
Summary
The current study aimed at genetic analysis of by Cirrhinus mrigala using mitochondrial DNA marker cytochrome oxidase I (COI). Genomic DNA isolated from whole blood was used to amplify and le sequence a short region of COI gene in mitochondrial DNA. The identification of sequenced samples was done by NCBI (98-99%) and BOLD (99%) databases. The sequence data analysis represented 15 rtic variable polymorphic sites and 4 haplotypes. Mean haplotypes and nucleotide diversity was 0.42 and. The mean intraspecific and intragenric K2P genetic distances were 0.2% and 1.2%, respectively. Rate of transitional and transversional substitution was 16.68% and 4.16%, respectively. The transition/transversion bias value R was 1.25. A showed a lack of neutral evolution and low genetic differentiation among populations of C. mrigala.
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