Abstract
Gastric ulcer is a disease that affects a large portion of the world population, with a prevalence of 2.4% in the Western population and annual incidence rates of 0.10% to 0.19%, with a high cure rate, but with a high recurrence rate. The aim of this research is to perform a literature review on the gastroprotective potential of the essential oil of Lippia gracilis Schauer. To this end, an integrative review study was carried out, which selected 26 scientific articles found in virtual platforms that approached the proposed theme. Based on the established criteria, the literature suggests that the essential oil of Lippia gracilis Schauer is a compound with several biological activities, including some already described in the literature, however, its gastroprotective potential is still lacking many evidences in the literature. The findings show that the EO of L. gracilis can delay and bring an improvement in the degree of involvement by the ulcerative disorder. However, new scientific approaches are necessary to better elucidate the effect of this oil, which can then become an additional therapeutic method for cases of gastric lesions.
Highlights
Gastric ulcer is characterized as a chronic disease and brings problems such as deep lesions in the gastric wall region, which invade and occupy the entire space of the mucosa
To guide the integrative review, the following question was formulated: "What is the scientific evidence in the literature about the gastroprotective effect of Lippia gracilis Schauer essential oil?" The search for primary studies was performed according to the criteria and manuals of each database
3.1 Lippia gracilis Schauer (Verbenaceae) essential oil The research and use of medicinal plants and herbal medicines for the treatment of various diseases are currently being stimulated by the government
Summary
Gastric ulcer is characterized as a chronic disease and brings problems such as deep lesions in the gastric wall region, which invade and occupy the entire space of the mucosa. Therapeutic methods consist of the use of proton pump inhibitors (e.g. omeprazole, pantoprazole, lansoprazole), histamine H2 receptor inhibitors (e.g. cimetidine, famotidine, nizatidine), antacids (e.g.: aluminum or magnesium hydroxide), antibiotics for H. pylori eradication (e.g. clarithromycin, amoxicillin), and gastric mucosal cytoprotective drugs such as prostaglandin analogues (e.g. misoprostol), carbenoxolone, and sucralfate (Fox; Muniraj, 2016). Even though these drugs improve or cure gastric ulcers, they can have certain types of adverse effects, such as diarrhea, abdominal pain, arrhythmias, and intolerance in the gastrointestinal tract, among others.
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