Abstract

The paper presents the full-size Russian corpus of Internet users’ reviews on medicines with complex named entity recognition (NER) labeling of pharmaceutically relevant entities. We evaluate the accuracy levels reached on this corpus by a set of advanced deep learning neural networks for extracting mentions of these entities. The corpus markup includes mentions of the following entities: medication (33,005 mentions), adverse drug reaction (1778), disease (17,403), and note (4490). Two of them—medication and disease—include a set of attributes. A part of the corpus has a coreference annotation with 1560 coreference chains in 300 documents. A multi-label model based on a language model and a set of features has been developed for recognizing entities of the presented corpus. We analyze how the choice of different model components affects the entity recognition accuracy. Those components include methods for vector representation of words, types of language models pre-trained for the Russian language, ways of text normalization, and other pre-processing methods. The sufficient size of our corpus allows us to study the effects of particularities of annotation and entity balancing. We compare our corpus to existing ones by the occurrences of entities of different types and show that balancing the corpus by the number of texts with and without adverse drug event (ADR) mentions improves the ADR recognition accuracy with no notable decline in the accuracy of detecting entities of other types. As a result, the state of the art for the pharmacological entity extraction task for the Russian language is established on a full-size labeled corpus. For the ADR entity type, the accuracy achieved is 61.1% by the F1-exact metric, which is on par with the accuracy level for other language corpora with similar characteristics and ADR representativeness. The accuracy of the coreference relation extraction evaluated on our corpus is 71%, which is higher than the results achieved on the other Russian-language corpora.

Highlights

  • Nowadays, Internet sources contain a vast variety of information subject to automated analysis by means of machine learning methods, the usage of which allows one to solve various socially significant tasks [1,2]

  • We present the full-size Russian-language corpus of Internet user reviews, named Russian Drug Reviews corpus of the SagTeam project (RDRS)

  • We describe the recurrent model that uses the chosen set of features as an input, the process of training a large language model to adapt it for texts of the target domain and the combination of models that we are using as the final pipeline for named entity recognition

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Summary

Introduction

Internet sources contain a vast variety of information subject to automated analysis by means of machine learning methods, the usage of which allows one to solve various socially significant tasks [1,2]. Such information is related to healthcare in general, consumption sphere and evaluation of medicines by the population. Clinical trials may not reveal all potential adverse effects of a medicine due to time limitations. Such information would be very useful for a PV database where the risks and advantages of drugs would be registered for the purpose of safety monitoring, as well as for forming hypotheses of using existing drugs for treating other diseases

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