Abstract
Objectives:To evaluate the relationship of D-dimer, CD147 and miR-203, and detect the influence of these biomarkers on the pathological characteristics in patients with gastric cancer.Methods:The patients with gastric cancer treated using radical gastrectomy between May 2013 and October 2017 were reviewed retrospectively. The expression of D-dimer, miR203 and CD147 was measured for all the patients, and the clinical data including age, gender, tumor size, tumor differentiation, invasion depth, lymphatic metastasis, TMN stage, and pathological type were retrieved and analyzed. The study was carried out in affiliated Yidu Central Hospital of Weifang Medical College, Qingzhou, China.Results:Two hundred sixty patients with gastric cancer were included. The patients with tumor metastasis, larger tumor diameter, lower differentiation, lymphatic metastasis, deeper invasion, and higher TMN stage presented with a significantly higher D-dimer and CD 147 expression, but the level of the two biomarkers didn’t show a significant difference in patients with different pathological type, gender and age. Compared with CD147 and D-dimer, miR203 presented with different characteristics of expression. In addition, the expression of miR203 was negatively correlated with CD147 and D-dimer, and there was a positive correlation between CD147 and D-dimer in patients with gastric cancer.Conclusion:In this study, a close correlation of D-dimer, miR203 and CD147 was found, and these three biomarkers should be screened in gastric cancer patients.
Highlights
Gastric cancer is the second leading cause of cancer-related death in the world, and its symptoms are mostly non-specific, which accounts for its delay in its early stage.[1]
In a study of 41 gastric cancer patients, Dian analyzed the plasma D-dimer levels and circulating tumor cells, concluded that D-dimer was an essential accompaniment of circulating tumor cells in gastric cancer, which can be used in the detection of hematogenous metastasis.[5]
Lin’s study provided a similar conclusion.[15]. We found those patients with tumor metastasis, larger tumor diameter, lower differentiation, lymphatic metastasis, deeper invasion, and higher TMN stage presented with a significantly higher D-dimer expression
Summary
Gastric cancer is the second leading cause of cancer-related death in the world, and its symptoms are mostly non-specific, which accounts for its delay in its early stage.[1] Subsequently, it is characterized by a poor survival rate due to late diagnosis[2], and its 5-year survival rate is under 20% for terminal gastric cancer.[3] As a result, early diagnosis is critical to improve the prognosis of gastric cancer. An exploration of the biomarkers involved in the progression of gastric cancer may facilitate its early diagnosis, and improve its prognosis. D-dimer is one of the terminal fibrin decomposition products, which can affect cellular signaling systems, promote cell proliferation, stimulate cellular adhesion of tumor cells to endothelial cells and affect platelets and extra-. These studies demonstrated that D-dimer was closely correlated with the progression of gastric cancer
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