Analysis of the expression and clinical significance of PGM5 in clear cell renal cell carcinoma based on the TCGA database

Abstract

To analyze the expression characteristics and clinical relevance of PGM5 in clear cell renal cell carcinoma based on the TCGA database. The differential expression of PGM5 and the association between PGM5 and clinical diagnosis and prognosis in clear cell renal cell carcinoma were analyzed based on the TCGA, GEIPIA, and Linkedomics databases. The R language was used to process and analyze data. The genes related to the expression of PGM5 were analyzed with the WebGestalt tool. The analysis based on the TCGA showed that the expression level of PGM5 mRNA in ccRCC tissues was lower than that in normal renal tissues. The Linkedomics database analysis showed that PGM5 mRNA is different expressed in the pathological Stage of the clear cell takes cell carcinoma (P < 0.05). The expression level tended to be downregulated with the happens of the pathological stage. PGM5 mRNA was differentially expressed in different T, N, and M stages (P<0.05). Survival analysis showed that PGM5 expression level was significantly associated with overall survival and disease-free survival in ccRCC patients. The diagnostic accuracy showed that the PGM5 expression had excellent diagnostic value by ROC curve analysis for distinguishing between ccRCC tissues and normal renal tissues. In addition, the expression level of PGM5 was positively correlated with that of PAPB, and PARM1, respectively, and negatively correlated with those of PMM2, NME1, and PDCD5. The enrichment analysis of genes associated with PGM5 expression was positively correlated with DNA replication and cell cycle and negatively correlated with those of cGMP-PKG and Rap1 signaling pathways. The expression level of PGM5 mRNA is associated with the pathological stage, T stage, N stage, M stage, and prognosis in patients with clear cell renal cell carcinoma. Therefore, PGM5 has the potential to become a diagnostic marker, as well as a therapeutic target of clear cell renal cell carcinoma.