Abstract
In the present work, a total of 132 HIV-1 env gene C2-V3-C3 sequences belonging to the IDU-A genetic variant were analyzed. The variants were obtained from the viruses circulating among IDUs and heterosexuals in the Perm region at different periods. It was shown that the rate of the divergence of the IDU-A HIV-1 viruses from a common ancestor increased 4.3 times (p < 0.001) in 2011 as compared with the onset of the epidemics. The rate of the HIV-1 evolution was different in the two risk groups of the infection. The mean genetic distance of HIV-1 variants circulating among heterosexuals was 1.3 times longer (p = 0.008) than that among IDUs. The accumulation rate of the nucleotide (including nonsynonymous) substitutions in the C2-V3-C3 HIV-1 env gene region among individuals infected by heterosexual contacts was 1.7 times higher than that among IDUs. The differences in the positions of the codons subjected to positive selection were demonstrated depending on the infection risk group tested.
Highlights
Проанализированы 132 генетические последовательности C2-V3-C3-области гена env Вирус иммунодефицита человека 1-го типа (ВИЧ-1) варианта IDU-A, полученные для вирусов, циркулировавших в разное время среди потребителей инъекционных наркотиков (ПИН) и гетеросексуалов на территории Пермского края
A total of 132 HIV-1 env gene C2-V3-C3 sequences belonging to the IDU-A genetic variant were analyzed
It was shown that the rate of the divergence of the IDU-A HIV-1 viruses from a common ancestor increased 4.3 times (p < 0.001) in 2011 as compared with the onset of the epidemics
Summary
Лебедев А.В.1, 3, Казеннова Е.В.1, Зверев С.Я.2, Нистратова Ю.И.2, Лага В.Ю.1, Туманов А.С.1, Глущенко Н.В.1, Ярыгина Е.И.3, Бобкова М.Р.1. В том числе несинонимичных замен в C2-V3-C3-области гена env ВИЧ-1 среди лиц, инфицированных гетеросексуальным путем, была в 1,7 раза выше, чем в группе ПИН. ANALYSIS OF THE env GENE VARIABILITY OF THE IDU-A HIV-1 VARIANT IN THE OUTBREAK OF THE HIV INFECTION EPIDEMIC IN PERM REGION OF RUSSIA (1996-2011). The mean genetic distance of HIV-1 variants circulating among heterosexuals was 1.3 times longer (p = 0.008) than that among IDUs. The accumulation rate of the nucleotide (including nonsynonymous) substitutions in the C2-V3-C3 HIV-1 env gene region among individuals infected by heterosexual contacts was 1.7 times higher than that among IDUs. The differences in the positions of the codons subjected to positive selection were demonstrated depending on the infection risk group tested.
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