Abstract
Abstract Objectives To evaluate the value of liquid-based cell examination combined with human papillomavirus (HPV) genotypes in the detection of cervical intraepithelial neoplasia. Methods A total of 21,155 patients who had undergone cytology, HPV genotypes and colposcopy-guided biopsy were grouped into three groups. Sensitivity, specificity, positive predictive value, and negative predictive value of the test methods of the three groups were compared. Results In the age group of less than 50 years, the sensitivity of HPV genotype testing was significantly higher than that of liquid-based cytology. The specificity of liquid-based cytology was significantly higher in all age groups than that of HPV genotype testing. The positive predictive value of each test index was higher in the age group less than 30 years, and the negative predictive value was higher in the 30–50-year age groups. In different age groups, liquid-based cytology and HPV genotype combined method can improve the sensitivity of detection and negative predictive values. Conclusions The HPV test has higher sensitivity and negative predictive value, and the cytology method is relatively specific and less sensitive. The combined method has better sensitivity and negative predictive value.
Highlights
The incidence of cervical cancer has become the second most common malignant tumor in the female reproductive system
The specificity of liquid-based cytology was significantly higher in all age groups than that of human papillomavirus (HPV) genotype testing
Liquid-based cytology and HPV genotype combined method can improve the sensitivity of detection and negative predictive values
Summary
The incidence of cervical cancer has become the second most common malignant tumor in the female reproductive system. The incidence of cervical cancer is related to the persistent infection of high-risk human papillomavirus (HPV) [1, 2]. Some women infected with the virus cannot eliminate themselves and continue to infect for more than a year, resulting in persistent HPV infection In this case, HPV infection develops into precancerous lesions of the cervix and eventually into cervical cancer [4,5,6]. Studies have shown that HPV-DNA-based screening technology is a more effective screening tool for cervical cancer than the other two alternative technologies. The World Health Organization’s recommendations for cervical cancer screening are based on HPV screening technology [7]. Persistent high-risk HPV infection is the main cause of cervical cancer. In the initial screening of cervical cancer, HPV genotype testing is more effective than cytology, relatively cheap and easy to operate, so the international guidelines recommend HPV genotype testing as the preferred screening method for cervical cancer [8, 9]
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