Analysis of the effects of vitamin d insufficiency on osseointegration of dental implants

Abstract

Background Vitamin D is a key factor in the union of innate and adaptive immunity, and its deficiency may influence on osseointegration process. Aim/Hypothesis the objective of this research was to investigate the effects of vitamin D insufficiency on osseointegration of dental implants. Our hypothesis is that the insufficiency of D vitamin can interfere on clinical osseointegration process. Materials and Methods Ten participants underwent 25-hydroxy-vitamin D (25- (OH) D) serum levels and were classified according to the Endocrine Society's Clinical Practice Guidelines- 5 participants with Vitamin D = 25- (OH)D-21 Insufficiency -29 ng ml (Group D-Insufficient) and 5 participants Sufficient in vitamin D = 25- (OH) D-30-100 ng ml (Control Group). Osseointegration was assessed through clinical, digital radiographic and Osstell ISQ imaging in the 3rd month after implant placement. Laboratory analyses included the evaluation of the gene expression of OPG RANKL in the two groups, at the time of implant implantation (Time 1) and at the time of reopening of the implant and clinical evaluation (Time 2). Results The clinical-radiographic results evidenced adequate clinical osseointegration in all participants of the research. The OPG RANKL levels did not present a statistically significant difference between the groups and or between the intervals of analysis. Conclusion and Clinical Implications This study concluded that despite altered serum levels of vitamin D, there is no clinical correlation with osseointegration deficiency and bone remodeling system. Considering the aspects evaluated in this research, D vitamin insufficiency is not a real contraindication for implant placement.