Analysis of the effectiveness of delayed cranioplasty of skull defects using nanocomposite metalloceramic in the experiment

Abstract

Objective. To substantiate the use of the nanocomposite metal ceramics for the delayed cranioplasty in rats in the experiment based on the analysis of the results of spiral computed tomography and morphological investigations. Materials and methods. In the experiment, a delayed cranioplasty with the use of nanocomposite metal ceramics was performed in 10 white rats (body weight 300–450 g, average age 6–8 months old). Results. SCT data showed an absolute consolidation of used grafts with bone defect. The nanocomposite metal ceramic implant showed a high effectiveness for replacement of the bone defects and for the forming of the regenerate with the active participation of the surrounding tissues, especially blood vessels invasion into the implant. Conclusions. 1. The experiments results confirmed the possibility of large-flap craniotomy with the following delayed cranioplasty in rat bucks using nanocomposite metal ceramic. 2. The use of the nanocomposite metal ceramic promotes to formation of newly formed bone tissue either dense or spongy one. 3. The use of nanocomposite metal ceramic may be recommended for clinical trials.