Analysis of the effect of subventricular zone in prognosis of patients with glioblastoma multiforme

Abstract

Objective To evaluate the relationship between subventricular zone(SVZ), the shortest distance from tumor centroid to the edge of the lateral ventricles (TV) and prognosis of patients with glioblastoma multiforme (GBM). Methods The clinical data of 130 patients with GBM in our hospital since 2006 to 2016 were retrospectively reviewed and 45 persons of these patients with SVZ were involved. Chi-square test and survival analysis was performed to identify prognostic factors associated with GBM. Results Chi-square test indicated that there were no significant differences in the distribution of age, gender, tumor location, tumor volume, preoperative epilepsy and the extent of resection in these two groups with involvement of SVZ or not (P>0.05). Similarly, there were no statistically significant differences in the distribution of age and sex, tumor location, tumor size, preoperative epilepsy between TV 0.05). Univariate analysis showed that adjuvant therapy (HR=0.765, 95% CI: 0.557-0.998, P=0.045), SVZ (HR=2.996, 95% CI: 1.995-4.500, P 0.05). When the parameters with statistical significance identified by univariate analysis were included in the multivariate analysis, the results showed that adjuvant therapy (HR=0.540, 95% CI: 0.333-0.875, P=0.012), SVZ (HR=2.634, 95% CI: 1.725-4.022, P 0.05). When the parameters with statistical significance identified by univariate analysis were included in the multivariate analysis, the results showed that adjuvant therapy (HR=0.726, 95% CI: 0.529-0.997, P=0.048) and TV(HR=3.234, 95% CI: 1.711-6.112, P<0.01) was independent prognostic indicator in patients of GBM with SVZ involvement (P<0.05). Conclusions Involvements of SVZ and TV less than 30 mm are the risk factors for the prognosis of patients with GBM. Key words: Subventricular; Glioblastoma multiforme; Prognosis; Neural stem cell