Analysis of the Effect of Hormone Therapy Combined with Hydroxychloroquine in the Treatment of IgA Nephropathy

Abstract

Objective: To explore and analyze the effect of hormone therapy combined with hydroxychloroquine in the treatment of IgA nephropathy. Methods: 30 patients with IgA nephropathy who were admitted to the Urology Department of Jiuquan hospital from August 2021 to May 2023 were selected as the research subjects, and they divided into an observation group and control group by drawing lots, with 15 cases in each group. The observation group underwent hydroxychloroquine treatment in addition of hormone therapy, and the control group underwent conventional treatment and hormone therapy. The rate of effectiveness of treatment, serum index, and renal function of both groups were compared. Results: The incidence of adverse reactions in the observation group was significantly lower than that in the control group (P < 0.05). There was no significant difference in serum creatinine and serum albumin (P > 0.05) between the groups before treatment; after treatment, the serum creatinine and serum albumin in the steroid group were significantly better than those in the reference group (P < 0.05). Besides, there was no significant difference in urine protein quantification and glomerular filtration rate between the groups before treatment (P > 0.05); after treatment, the hormone group’s urine protein quantification and glomerular filtration rate were significantly better than those in the reference group (P < 0.05). The rate of effectiveness of the hormone group was significantly higher than that of the reference group (P < 0.05). Conclusion: Hormone therapy combined with hydroxychloroquine in the treatment of IgA nephropathy is more effective than hormone therapy alone, thus this treatment plan is worthy of promotion and application.