Abstract
5518 Background: EGFR plays a major role in cell proliferation. EGFR overexpression is strongly associated with poor prognosis in HNC patients. First intron of EGFR gene contains a highly polymorphic microsatellite sequence (9 to 23 CA-repeats) and in vitro transcription declines with increasing number of repeats. We analyzed EGFR gene polymorphism and EGFR expression in tumor (T) and normal mucosa (N) of HNC patients. Methods: T biopsies (initial diagnosis) were taken in 113 patients (mean age 60, 101 men, 12 women; 13 stage II, 21 stage III, 79 stage IV; 53 cancer-related deaths) along with N biopsies for 100 patients. EGFR levels were measured by ligand-binding assay. The microsatellite marker was analyzed by semi-automated fluorescent genotyping. Prognostic values of EGFR genotype and expression on specific survival were analyzed by multivariate Cox regression including performance status and node involvement. Results: Number of CA repeats varied from 13 to 22. Allelic distribution in tumor was trimod...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
