Abstract
Cervical cancer is a kind of common gynecological malignancies. Although human papillomaviruse (HR-HPV) persistent infection is considered as the main cause of cervical cancer, the epigenetic regulation also plays an important role in the cancer development. Studies indicate that microRNAs(miRNAs)are differentially expressed at different levels of the cervical cancer, and are involved in various biological processes of the cervical cancer. In this study we analyzed the miRNAs expression profiles at different stages of the cervical cancer from 85 original experimental articles by systematic analysis method, and classified them into four different pathological grades including the cervical intraepithelial neoplasia (CIN1-3) and the cervical cancer. The results will provide a theoretical basis for evaluating the clinical application value of the differentially expressed miRNAs in the early diagnosis and the prognosis of cervical cancer. Key words: Cervical cancer; MicroRNAs(miRNAs); Differential expression
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