Analysis of the curative effect of 86 cases of non-small cell lung cancer after comprehensive treatment

Abstract

Objective To analyze the effect of surgery, chemotherapy, radiotherapy or combined therapy on 86 patients with non-small cell lung cancer(NSCLC), and to investigate the corresponding clinical value. Methods A retrospective study was performed on 86 cases of patients with NSCLC, who were admitted from February 2014 to December 2017.According to the different treatment methods, there were 26 cases in the radiotherapy group, 28 cases in the surgical group, and 32 cases in the surgical + radiotherapy group.Kaplan-Meier method was used to calculate and statistically analyze the survival of the patients.Stratified analysis was conducted on the distribution of the three groups of patients in different clinical stages.Finally, complications caused by the three different treatment methods were observed. Results In the radiotherapy group, the number of patients in complete remission, partial remission, no change and disease progression was 9, 11, 4 and 2, respectively.There were 11, 15, 0 and 2 patients in the surgical group with complete remission, partial remission, no change and disease progression, respectively.The number of patients in the surgical + radiotherapy group with complete remission, partial remission, no change and disease progression was 23, 7, 1 and 1, respectively.The three groups had statistically significant differences in population distribution(χ2=15.759, P=0.015). The result of chi-square test showed that there was no statistically significant difference between the radiotherapy group and the surgical group(χ2=4.748, P=0.191). There was statistically significant difference in treatment effect between the surgical + radiotherapy group and the radiotherapy group(χ2=8.057, P=0.045). There was statistically significant difference in treatment effect between the surgical + radiotherapy group and the surgical group(χ2=8.248, P=0.041). The 1-year, 2-year and 3-year survival rates of patients in the surgical + radiotherapy group was 56.3%, 21.9% and 28.6%, respectively, which were statistically significant different from those in the radiotherapy group(100%, 0, 0)and the surgical group(75.0%, 17.9% and 7.1%, P>0.05). According to patients′clinical stage, in period of Ⅰ, Ⅱ, Ⅲ and Ⅳ, there were 7, 5, 5, 9 cases in the radiotherapy group; 8, 6, 6, 8 cases in the surgical group; 1, 2, 11, 18 cases in surgical + radiotherapy group(χ2=13.993, P=0.030). Two groups of chi-square test showed that the radiotherapy group and the surgical group had no statistically significant difference(χ2=0.234, P=0.972), the surgical + radiotherapy group and the radiotherapy group had statistically significant difference(χ2=10.528, P=0.015), the surgical + radiotherapy group and the surgical group had no statistically significant difference(χ2=12.550, P=0.006). Complications of the patients in the three groups showed that 15 cases(57.7%)of the 26 patients in the radiotherapy group presented symptoms of radiation pneumonia, 13 cases(50.0%)presented symptoms of radiation esophageal inflammation, and 8 cases(30.8%)of both complications.There were 15 cases(53.6%)in the surgical group presented symptoms of radiation pneumonia, 12 cases(42.9%)presented symptoms of radiation esophageal inflammation, and 7 cases(25.0%)of both complications.There were 32 cases in the surgical + radiotherapy group, 8 cases(25.0%)presented symptoms of radiation pneumonia, 5 cases(15.6%)presented symptoms of radiation esophageal inflammation, and 2 cases(6.3%)of both complications.Three groups of patients were compared in radiation pneumonia, radiation esophagitis and their combination, and the differences were statistically significant(χ2=7.700, 8.624, 6.154; P=0.021, 0.013, 0.046). Further analysis showed that compared with the surgical + radiotherapy group, the incidence of complications was higher in both the radiotherapy group and the surgical group(P<0.05). Conclusion Comprehensive treatment is significantly better than single treatment, not only in the survival rate, but also in reducing the complications after treatment, the prognosis is better, and then it is suggested that there are differences in treatment methods in different clinical stages, clinically should be given more attention. Key words: Non-small cell lung cancer; Comprehensive treatment; Clinical stage; Complication; Lung tumor; Lung cancer