Analysis of the correlation factors of bronchiolitis and asthma in children caused by MP infection

Abstract

Objective To analyze the correlation factors of bronchiolitis and asthma in children caused by MP infection. Methods 136 children who were diagnosed with bronchiolitis in pediatric department of our hospital from January 2011 to January 2014 were selected, whose MP-IgM antibodies in serum were positive through the ELISA method. The clinical data of these cases during hospitalization was collected, and the objects of study received telephone or outpatient follow-up of 3-5 years, including whether use of IVIG during hospitalization, whether the time of breastfeeding longer than 4 months, whether a history of BCG vaccination, whether a history of eczema, whether a family history of allergic diseases (allergic rhinitis, asthma) in first degree relative, whether continuous use of montelukast for 3 months after discharge; according to whether the occurrence of children asthma during 3-5 years, the correlation factors of bronchiolitis and asthma in children caused by MP infection were analyzed by the Chi-square test and Logistic regression method. Results During the telephone or outpatient follow-up of 3-5 years, 16 cases were lost, there were 43 cases of children asthma in the remaining 120 cases, with the incidence of 35.83%. The time of breastfeeding longer than 4 months, the history of BCG vaccination, continuous use of montelukast for 3 months after discharge were protective factors of children asthma and bronchiolitis caused by MP infection; the history of eczema, the family history of allergic diseases (allergic rhinitis, asthma) in first degree relative were high risk factors (P<0.05). Conclusion The history of eczema, the family history of allergic diseases (allergic rhinitis, asthma) in first degree relative are high risk factors of children asthma and bronchiolitis caused by MP infection; the time of breastfeeding longer than 4 months, the history of BCG vaccination, continuous use of montelukast for 3 months after discharge are protective factors. Therefore, the high risk factors of bronchiolitis caused by MP infection should be paid high attention to, and early intervention should be carried out; and the protective factors should be strengthened, so as to reduce the incidence of asthma in children. Key words: Mycoplasma pneumoniae infection; Bronchiolitis; Asthma in children; Related factors