ANALYSIS OF THE CONNECTIVE TISSUE COMPONENTS IN THE ORAL FLUID OF CHILDREN SUFFERING FROM CHRONIC CATARRHAL GINGIVITIS UNDER CONDITIONS OF DIFFUSE SIMPLE GOITER

Abstract

Objective - to study changes of the quantitative and qualitative content of the proteincarbohydrate complexes in the oral fluid of children suffering from chronic catarrhalgingivitis (CCG).Material and methods. 85 children aged 12-15 years were examined. Two groups of observation were formed: I group - somatically healthy children (40 individuals); II group -children with diffuse simple goiter (DSG) (45 individuals). Subgroups were isolatedwithin every group depending on availability or lack of differences in patients with CCG:ІА - somatically and stomatologically healthy children (n=20); ІB - somatically healthychildren with CCG (n=20); ІІА - children with DSG without lesions of the periodontaltissues (n=22); ІІB - children with DSG and CCG (n=23). Oral fluid was used for paraclinical examination. The whole protein level, glycoprotein concentration, hexosaminecontent, the level of fucose and sialic acids were used.Results. When inflammatory process develops in the gums, an average level of protein inthe oral fluid 60% increases and it is (3,39±0,24) g/L. In case somatic pathology joins theprotein level increases considerably. At the same time, the content of proteincarbohydrate complexes several times decreases. The protein level increases significantlyunder conditions of somatic pathology joining.Contrary to the changes of amino sugars concentration in the oral fluid of children fromthe experimental groups, the level of terminal carbohydrate glycoprotein residuesincreases, which is indicative of disorders of the saliva protector properties.Conclusions. 1. Glycoprotein level decreases in the oral fluid of children with CCGagainst a background of an increased protein level. These changes intensify with comorbid DSG, which may be indicative of a partial breakdown of protectiveaminopolysaccharides performing a protective saliva function. 2. A reliable decrease ofhexosamines in the oral fluid of children with both CCG and thyroid pathology is found,which correlates with an increased level of terminal carbohydrate residues - sialic acidsand fucose, and is indicative of disorders in glycoprotein synthesis in the glandularstructures.