Analysis of the Clinicopathologic Characteristics of Lung Adenocarcinoma With CTNNB1 Mutation.

Chao Zhou,Jinchen Shao,Jikai Zhao,Wentao Li,Chang Chen

doi:10.3389/fgene.2019.01367

Abstract

IntroductionLung adenocarcinoma with CTNNB1 mutation is relatively uncommon, and its clinicopathologic characteristics, disease course, and prognosis have not been well-studied.MethodsA total of 564 lung adenocarcinoma patients were enrolled in this study. The relationship between CTTNB1 mutational status and clinicopathologic parameters, the rates of relapse-free survival (RFS) and overall survival (OS), and the mutational status of other genes commonly mutated in lung adenocarcinoma were analyzed.ResultsOf 564 lung adenocarcinoma patients, 30 (5.3%) harbored CTNNB1 mutations. Univariate analyses revealed that gender, smoking history, pleural invasion, and histological subtype were all significant predictors of RFS and OS. Pleural invasion and histological subtype remained significant predictors of RFS and OS in a multivariate analysis. There were no significant differences in RFS (p = 0.504) or OS (p = 0.054) between lung adenocarcinoma patients with CTNNB1 mutation and those without CTNNB1 mutation. However, patients with CTNNB1 mutation tended to have a worse OS.ConclusionsFemale patients and nonsmokers are likely to harbor CTNNB1 mutation and primary lung adenocarcinoma with mutated CTNNB1 has a poor prognosis.

Highlights

Lung adenocarcinoma with CTNNB1 mutation is relatively uncommon, and its clinicopathologic characteristics, disease course, and prognosis have not been well-studied
Woenckhaus et al (2008) identified a number of differentially expressed genes in smoke-exposed bronchial epithelium and nonsmall cell lung cancers (NSCLCs), they found in adenocarcinomas, the cytoplasmic expression of beta-catenin was associated with shorter survival (p = 0.012)
Univariate analysis revealed that gender, smoking history, pleural invasion, and histological subtype were all significant predictors of Relapse-free survival (RFS) and overall survival (OS) (Table 3)

Summary

Introduction

Lung adenocarcinoma with CTNNB1 mutation is relatively uncommon, and its clinicopathologic characteristics, disease course, and prognosis have not been well-studied. Mutations in the gene encoding b-catenin (CTNNB1) have been detected in numerous human malignancies, including lung cancer (Woenckhaus et al, 2008), malignant mesothelioma (Shigemitsu et al, 2001), desmoid tumors (Colombo et al, 2013), colon cancer (Akyol et al, 2019), and others. Woenckhaus et al (2008) identified a number of differentially expressed genes in smoke-exposed bronchial epithelium and nonsmall cell lung cancers (NSCLCs), they found in adenocarcinomas, the cytoplasmic expression of beta-catenin was associated with shorter survival (p = 0.012). The immunohistologic loss of b-catenin membrane staining along with a corresponding increase cytoplasmic or nuclear staining has been reported (Nozawa et al, 2006)

Methods

Results

Conclusion