Analysis of the clinical outcome of 10 690 artificial insemination cycles with donor sperma

Abstract

Objective To analyze the effects of various factors on the clinical outcome of artificial insemination with donor sperm (AID). Methods A total of 10 690 AID cycles were analyzed between 2013 and 2015 in our center. The relationship between the clinical outcome and the factors, such as woman's age, duration of infertility, therapeutic regimen, fallopian tube patency, endometrial thickness, number of eggs ovulated per cycle, number of insemination per cycle, sperm concentration after thawing, sperm activity ratio after thawing and the total number of progressively motile sperm was analyzed by c2 and multiple factor Logistic regression. Results The pregnancy opportunity was 1.934 times of women who were younger than or equal to 30 years (OR=1.934, P<0.001) and 1.511 times of women aged 31-35 years (OR =1.511, P<0.001) as high as those who were older than 35 years. It was 1.307 times of women received the natural cycle as high as that of women received ovulation induction cycle (OR=1.307, P<0.001). It was 1.486 times of women received double inseminations per cycle (OR=1.486, P=0.001), and 1.338 times of women received three inseminations per cycle (OR=1.338, P=0.020) as high as that of women received one insemination per cycle. It was 1.362 times of women with 2 eggs ovulated per cycle (OR=1.362, P=0.001), and 1.499 times of women with 3 eggs ovulated per cycle (OR=1.499, P=0.004) as high as that of women with one egg ovulated per cycle. It was 1.211 times of women received sperm with sperm activity ratio more than 60% after thawing as high as that of women received sperm with sperm activity ratio less than or equal to 60% after thawing (OR=1.211, P=0.038). It was 1.319 times of women received the progressively motile sperm more than or equal to 35×106 after thawing as high as that of women received the progressively motile sperm less than or equal to 25×106 after thawing (OR=1.319, P=0.011). Conclusion Many factors such as woman's age less than or equal to 35 years, double or three inseminations per cycle, 2 or 3 eggs ovulated per cycle, sperm activity ratio more than 60% after thawing and the progressively motile sperm more than or equal to 35×106 after thawing can improve the pregnancy rate. In the case of patients with no obvious ovulation disorders, natural cycle should be preferred. Key words: Artificial insemination with donor sperm (AID); Pregnancy; Logistic regression