Analysis of the clinical features and prognostic factors of patients with gastroesophageal reflux disease

Abstract

Objective To investigate the clinical features and prognostic factors of patients with gastroesophageal reflux disease(GERD). Methods The clinical data of 62 cases of GERD patients with esomeprazole therapy(GERD group) in the Central Hospital of Chaoyang from February 2012 to December 2015 was analyzed, and 65 cases of chronic superficial gastritis were served as control group.The Hamilton Depression Scale(HAMD) and Hamilton Anxiety Scale (HAMA) score of two groups were observed.The relationship between RDQ score, HAMD score and HAMA score in patients with GERD was analyzed, and the influence factors of the treatment efficacy were analyzed by Logistic. Results HAMD score, HAMA score of GERD group were (19.8 ±7.9) points, (15.9 ±5.6) points, and of control group were (7.9± 1.2) points, (6.7 ±1.0) points, the difference between the two groups was statistically significant(P<0.05 ). HAMD, HAMA and RDQ scores were positively correlated of GERD group(correlation coefficients were 0.401, 0.382, P<0.05). Two months after treatment with esomeprazole, there were 34 cases with markedly effective, 10 cases with effective, 18 cases with invalid, and the remission rate was 71%(44/62). Multivariate logistic regression analysis showed that non erosive peptic esophagitis(NERD)(OR=2.483, 95%CI: 1.247-4.944, P<0.05) and female(OR=2.421, 95% CI: 1.259-4.657, P<0.01) were the independent predictor of esomeprazole in the treatment. Conclusion GERD patients are accompanied by depression and anxiety and other psychological symptoms, the clinical symptoms of some patients with PPI treatment still cannot be alleviated.NERD subtype, female and depression anxiety are the main factors affecting the treatment effect. Key words: Gastroesophageal reflux disease; Non erosive gastro esophagitis; Reflux esophagitis; Esomeprazole; Logistic regression analysis