Abstract
ABSTRACTBackground: Clinical characteristics are keys to improve identification and treatment of Crohn´s disease (CD) so that large sample analysis is of great value. Aim: To explore the clinical characteristics of perianal fistulising CD. Methods: Analysis of 139 cases focused on their clinical data. Results: The proportion of males and females is 3.3:1; the mean age is 28.2 years; 47.5% of patients had anal fistula before CD diagnosis. Patients with prior perianal surgery and medication accounted for 64.7% and 74.1% respectively. The L3 type of lesion was present in 49.6% and the B1 and B2 types for 51.8% and 48.2% respectively; complex anal fistula was diagnosed in 90.6%. Symptoms of diarrhea were found in 46% and perianal lesions alone in 29.5% of patients. Abnormal BMI values was present in 44.6%; active CD activity index in 64.7%; and 94.2% had active perianal disease activity index. A proportion of patients manifest abnormal C-reactive protein, erythrocyte sedimentation rate, platelet, hemoglobin and albumin. Conclusion: We suggest that patients with anal fistula associated to these clinical features should alert the medical team to the possibility of CD, which should be further investigated through endoscopy and imaging examination of alimentary tract to avoid the damage of anal function by routine anal fistula surgery.
Highlights
Anal fistula is the most common perianal lesion of Crohn’s disease (CD)
The objective of this study was to explore the clinical features of anal fistula in CD to better indicate the appropriate treatment
Research subjects and observation indexes Cases of 139 perianal fistulising CD patients, who were first admitted to the Affiliated Hospital of Nanjing University of Chinese Medicine from January 2010 to January 2017, were registered to collect their gender, age, CD course, anal fistula course, body mass index (BMI), Montreal classification, anal fistula type, external opening number, concomitant perianal lesions, clinical symptoms, abdominal surgery history, perianal surgery history, medication history, CD activity index (CDAI), perianal disease activity index (PDAI) and laboratory analyses, as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), leukocyte (WBC), platelet (PLT), hemoglobin (HB), albumin (Alb)
Summary
Background: Clinical characteristics are keys to improve identification and treatment of Crohns disease (CD) so that large sample analysis is of great value. To explore the clinical characteristics of perianal fistulising CD. The objective of this study was to explore the clinical features of anal fistula in CD to better indicate the appropriate treatment
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
