Analysis of the characteristics of coronary artery lesions in patients with obstructive sleep apnea-hypopnea syndrome and influencing factors

Abstract

Objective The current study involved an analysis of the characteristics of coronary artery lesions of patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and the corresponding influencing factors. Methods One hundred twenty patients were selected by sleep apnea monitoring and coronary angiography. According to the apnea-hypopnea index (AHI), the patients were divided into the following 3 groups: patients with an AHI 15 times/h as the moderate-to-severe OSAHS group (n=63). The clinical and laboratory test data of patients in each group were collected. A single-factor ANOVA and multi-factor logistic regression analysis were performed on the study data to analyze the coronary artery lesions in patients with OSAHS and the corresponding influencing factors. Results (1) With respect to smoking, alcohol consumption, BMI, blood glucose, blood lipids, and blood pressure among the three groups, there were no significant differences between the three groups; however, age did differ among the three groups (P Conclusion The probability of coronary artery lesions increased with OSAHS severity. The main manifestation of the increased possibility was single-vessel coronary artery lesions. In single-vessel disease, the anterior descending branch and the right coronary artery were the most vulnerable, which may be related to the anatomic distribution. Alcohol consumption, age, and AHI are the major risk factors for coronary artery lesions. Alcohol consumption and AHI are major risk factors for single-vessel disease. Age is the main risk factor for multi-vessel disease.